It's just another day at the office for Detective Edgar "Lefty" Mendieta: abandoned by the woman he loves, demoralized by his city's (nad his nation's) ubiquitous corruption, and in dire need of some psychotherapy. Against this backdrop, he catches the case of Bruno Canizales, a high-powered lawyer with a double life, who was killed by a single silver bullet.
Throwing himself into his work, Mendieta begins to piece together the details of Canizales' life. The son of a former government minister, and the lover of a drug lord's daughter, Canizales it seems had a penchant for cross-dressing and edgy sex.
In the sweltering city of Culiacán, Mexico's capital of narco-crime, Mendieta scrambles to follow several leads. His dogged pursuit of the killer takes him from glitzy mansions to drug dens, from down-at-the-heels reporters to glamorous transsexuals. When a second, apparently related murder surfaces, Mendieta discovers that his desire to unearth the truth has become as overpowering as any drug.